Cook was tended to on the field by trainers before walking off on his own power back to the Vikings locker room with head team trainer Eric Sugarman. The Vikings came into the game second in the National Football League on offense, averaging more than 400 yards per game.
Cook suffered an apparent knee injury on the play and did not return.
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Cook's injury and fumble occurred on the next drive, and the Lions countered with Abdullah's touchdown and a two-point conversion to TJ Jones for the lead. The NFL's highest paid player in history completed 19 of his 31 passes for 209 yards, no touchdowns and no interceptions. They sacked Detroit quarterback Matthew Stafford six times. "He has such great big-play ability, so we'll have to look at things differently, but if you lose a guy like him, you lose a lot of firepower".
Cook scored Minnesota's lone touchdown and had 13 carries for 66 yards, along with an 8-yard reception, prior to his injury. He ranked second in rushing yards, gaining almost five yards per carry and flashed the ability to be a weapon in the passing game with five catches for 72 yards against the Bucs.
The Vikings brought running back Jerick McKinnon in as a wildcat quarterback in the third quarter, but he fumbled the handoff, leading to a Lions field goal.