"The effects were very mild even after six weeks of regular consumption of ibuprofen, which is longer than is usually recommended in practice, so this data should not concern men who occasionally take ibuprofen for pain relief", added Imperial College London senior clinical lecturer in endocrinology Ali Abbara. Sold under the brand names Advil or Motrin, ibuprofen is a member of the class of drugs known as NSAIDS (nonsteroidal anti-inflammatory drugs).
However, despite the change in LH levels, the men's testosterone levels didn't change.
Scientists analyzed the hormones and blood of a group of 31 healthy white men between 18 and 35 years old over the course of six weeks. This indicates that they had developed a condition called "compensated hypogonadism", which happens when testosterone production is reduced, but the body is able to compensate by increasing LH levels, the researchers said.
Compensated hypogonadism is typically found in elderly men and has been associated with reproductive and physical disorders, according to the researchers.
'Unfinished business': Raiders announce Jon Gruden's return
Gruden was 3-1 at Arrowhead in his first stint with the Raiders and won a road game there with Tampa Bay in 2008. The team announced the move Saturday as soon as Gruden finished his final broadcast as an announcer for ESPN.
This study might be especially troubling for athletes; Bernard Jégou, one of the study's co-authors, told CNN that many athletes take ibuprofen regularly to combat the aches and pains that accompany their sport, and warns that long-term usage like this could do irreversible damage.
"These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines", David Møbjerg Kristensen at the University of Copenhagen told the newspaper. Before he stepped down in November 2016 he asked players about their use of over-the-counter painkillers and found that almost half of those who played in the past three World Cups took anti-inflammatory drugs, such as ibuprofen, every day. "The risk is greater than the benefit".
"The study shows that ibuprofen use results in selective transcriptional repression of endocrine cells in the human testis", the significance on the PNAS site reads.
The hormonal imbalance caused compensated hypogonadism, which is a condition linked to decreased male fertility, depression, and an increased risk of heart attack or stroke.