And that appeared to work like a charm, as leaders City blew Leicester away at the Etihad Stadium.
And he took his season tally to 21 late on, smashing in off the crossbar from 25 yards. Leciester boss Claude Puel will be frustrated by the result, but the two players are at least a threat to any side in the country.
With the pair ably backed by a sensational supporting cast, including Leroy Sane, David Silva, Raheem Sterling and Gabriel Jesus, City have scored 20 more goals than the next-best attacking side, Liverpool, and amassed 16 points more than city rivals United, in second place.
Raheem Sterling got proceedings underway inside three minutes, and while Leicester were level for almost 25 minutes, there were two undoubted stars of the show.
With 48 minutes gone, and the score level at 1-1, De Bruyne played a give and go with Sterling on the left wing and cut inside. Talismanic Belgium pass master, Kevin De Bruyne, located Sterling with his trademark passes for the opener of the game.
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As he reached the edge of the area he connected with a firm shot and a slight deflection off Aymeric Laporte took it flying past Ederson for an equaliser.
The Algerian winger was back to his title-winning form in the first half of the season - with eight Premier League goals - before he was unsettled by City's late interest in the window.
Puel's decision to switch to a back four, with the introduction of Danny Simpson at half-time, did little to shore up Leicester's backline as Aguero scored twice in five minutes succession shortly after the interval to effectively end the game as a contest.
Just before the break, Sterling had an opportunity to restore the advantage as he picked up another excellent pass into the area by De Bruyne before rounding Schmeichel.
Sergio Aguero completed his second-half hat-trick in the 77th minute, when the Argentine took a gift and extended the Blues' lead to 4-1.
Much of the build-up was dominated by Riyad Mahrez's return to Leicester's squad after missing 10 days of training in response to not securing a move to the hosts, but he was benched as City - who were afforded a few days off beforehand - ultimately cruised, with De Bruyne and Aguero stealing the show. However, it was the City fans that roared the loudest with two more goals from Aguero.