Nemanja Matic bagged the victor in the 91st minute with the Serbian global rocketing a thirty-yard effort into the net.
Matic has managed to claim the accolade four times since his debut with the club, after he was named Man of the Match in their 4-0 wins over West Ham and Everton, and in the 2-1 victory against West Brom Albion back in December.
United completely failed to react to a quick free-kick taken by the hosts, allowing Patrick van Aanholt to go clean through on goal - the left-back made no mistake, blasting the ball past David De Gea at his near post. Even at 2-0, one who's watched his team home and away since the 70s said: "I'd settle for a draw now".
"It was a hard match for me because my team made so many mistakes".
Mourinho had at half-time introduced Marcus Rashford for Scott McTominay and adopted a more attacking shape, and after Palace went 2-0 up it began to show. Their second goal made things much more hard for us, but Chris Smalling's goal was very important.
West Virginia educators make history, give lawmakers a civics lesson
Here & Now's Peter O'Dowd speaks with Kevin Green , a teacher in Bradshaw, West Virginia. But the Senate refused to go along, approving a 4 percent increase.
After hitting back from a goal down to beat Chelsea last weekend, Mourinho insisted this was another demonstration that United have the spirit and desire to overcome perilous predicaments.
The rivalry between Liverpool and United is intense and as a kid growing up as a Red on Merseyside, this was the fixture that I always watched while hiding behind the back of my sofa and it will be no different all these years on Saturday.
Benteke missed a good chance to restore Palace's two-goal cushion when he glanced Van Aanholt's cross wide, but made amends by clearing Matic's powerful shot off the line moments later at the other end.
The Red Devils looked down and out early in the second half last night as they went two goals behind.
"Not many, but he's scored a few goals - this season against Benfica [it was] half of the goal for him, half of the goal for the Benfica goalkeeper".
Smalling feels it must have been disheartening for Manchester United's league rivals to see them coming back in such a manner at a hard away ground such as Selhurst Park.