The temblor hit beneath the Pacific Ocean about 12:29 p.m., at a depth of about 10 miles beneath the surface, USGS reported.
The U.S. Geological Survey initially reported the shaker was a magnitude-5.0, but it was later upgraded to magnitude-5.3.
No significant damage was reported, but some bricks fell from a chimney at a historic ranch on one of the islands.
Some people in the Los Angeles area received about a 10-second warning before the shaking hit thanks to the state's quake early warning system, according to seismologists at the California Institute of Technology.
Asked was it likely to follow typical aftershock patterns, Hough said "We can never count on earthquakes to obey the averages" but said that they did expect an aftershock pattern, most likely peaking in the magnitude 4 range.
Studio Ghibli co-founder Isao Takahata passes away
His extensive TV credits included the 1970s series Heidi , Girl of the Alps , based on the novel by Swiss author Johanna Spyri. While Hayao Miyazaki remained the best known director at Ghibli, Isao Takahata made some of the studio's most beloved movies.
Los Angeles Fire Department Chief Ralph Terrazas said the department was in "earthquake mode", which he added was standard protocol.
A USGS ShakeMap shows an natural disaster that struck off the Channel Islands on April 5, 2018.
Most of Santa Cruz Island, including the ranch area, is owned by The Nature Conservancy, which cooperatively manages the island with the Park Service.
The shaking caused landslides on Santa Cruz Island, which was close to the epicenter.
It was felt across the Los Angeles area and as far away as Bakersfield.
Netizens have since taken to social media to react to the tremble.