In Godin and Jose Gimenez, Uruguay have one of the most priceless commodities in global football - a centre-back pairing which plays together week in and week out for Atletico Madrid.
"Their central defenders play for Atletico Madrid, who won the Europa League".
And Uruguay has identified Ronaldo, with four goals so far at Russian Federation 2018, as the biggest threat to their hopes of a place in the last eight. "You don't prepare a match just looking at one player".
The squad is fully fit and nobody is suspended, but boss Fernando Santos has some big decisions to make.
European champions Portugal, however, finished second in their section to set up a clash with Uruguay in the last 16.
For Ronaldo it is a return to the same Fisht Stadium where he scored a hat-trick against Spain earlier in the tournament, but this time he will be up against a Uruguayan defence that was alone among the 32 teams in Russian Federation in coming through the group stage without conceding a goal.
Tabarez has led Uruguay for 12 years, restoring the small South American nation as a footballing power once again.
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In that two against one, Ronaldo doesn't compare too badly.
Tabarez, who is in his 14th year as Uruguay manager, albeit across two spells, is understandably planning that his side will have to work as a team to contain the five-time Ballon D'Or victor.
Which TV channels will broadcast the FIFA World Cup 2018 Uruguay vs Portugal Round of 16 match? - Cristiano Ronaldo has so far failed to score a single goal for Portugal in the knockout stages of the World Cup: 424 minutes, 0 goals.
That, and Portugal's recent track record of being involved in tense knockout matches that have gone to the wire, has raised the prospect of a nail-biting contest as the World Cup heads into its latter stages.
Ronaldo began the tournament in spectacular fashion, with his stunning free kick completing a hat trick and snatching a 3-3 draw against Spain at Fisht Stadium.
The 2018 FIFA World Cup kicked off on June 14 and will continue until July 15, with the matches being played in 11 cities across Russian Federation.
Who wins Portugal-Uruguay? And where does all the value lie?
"I am a lot better than in the first game", Suarez told reporters ahead of facing Portugal on Saturday.