When the scene goes back to Earth, it's revealed the three have been erased as a result of Thanos' finger snap in Avengers: Infinity War.
The Marvel Cinematic Universe has had issues for years with how, exactly, its timeline fits together, which is a natural issue when you're mixing together the continuity of over a dozen films into one cohesive timeline.
Ant-Man and the Wasp marks the 20th installment in the Marvel Cinematic Universe, and for much of the last decade, the blockbuster saga has been a box office-conquering behemoth - a series of nested franchises in constant concentric motion, with an increasingly unwieldy narrative ambition to match its growing financial stakes. Deadline reports that after the film's Thursday night opening, Ant-Man and the Wasp is off to a $11 million start, "with some sources believing the movie could see an even bigger growth spurt north of $13M+". Since they are under house arrest, they can not participate in the fight in Infinity War.
"They go in the end, but I don't like that staggering".
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This image released by Marvel Studios shows Evangeline Lilly, left, and Paul Rudd in a scene from Ant-Man and the Wasp. In the aftermath of "Infinity War", in which the villain Thanos used the all-powerful Infinity Stones to wipe out half the life in the universe, access to the Quantum Realm could provide Ant-Man and the other superheroes with a means to stop Thanos in the past to alter the present. Fans learn that Scott Lang took the Ant-Man suit from his mentor Hank Pym (Michael Douglas) without permission when he flew to Germany to help Captain America (Chris Evans) fight Iron Man (Robert Downey Jr.) in Civil War. All is resolved with no hint that Thanos has yet attacked Earth.
The first post-credits scene finds Scott venturing back into the Quantum Realm to gather more healing particles to continue Ghost's treatments, with Hope, Hank, and Janet staying behind to operate the Quantum Gateway tech, which is now stashed in the back of Luis' van.
Scott's ant friend cuts loose in Ant-Man and the Wasp. Scott, Hope, Hank and Janet are working on an experiment, seemingly blissfully unaware of the impending doom. But with Scott presumably trapped inside the Quantum Realm, it remains to be seen how he will escape. But while he is in the Quantum Realm, he loses contact with the Pym family. Like dozens of characters in Avengers: Infinity War, they have disintegrated and floated away.
Then there's the fact that time and space work completely differently down there - Hank, in the first Ant-Man, says those concepts are "irrelevant" as far as the quantum realm is concerned. Maybe they thought he was still under house arrest.